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Evidence is increasing that all addiction without exception is related to problems with the brain's reward center, particularly the mesolimbic system. This area of the problem regulates reward responses in establishing food and sex, as well as in nurturing infants and children. One of the most important neurotransmitters linked to reward responses, both after they malfunction and whenever they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the quantity of dopamine released in in reaction to a stimulus"(Bostwick & Bucci, 2008). Using two separate drugs to shed weight can be very effective you'll find combinations as you're watching FDA now awaiting approval. When dealing with weight reduction and the people who go through it you ought to err on the side of caution and allow the FDA do its job and demand some investigation be done so your public is aware of the side effects and perils associated with the medications before we take them. Keep in mind that drug companies come in business to make money and that they would say almost anything to keep people on his or her medications. Researchers found that participants investing in this drug for any year, lost weight within four weeks and have kept the extra weight off through the 56 weeks in the study. Contrave is really a combination with the drugs naltrexone and bupropion, which generally seems to reflect a whole new trend of weight-loss drugs which are made up of many active ingredient, which may make them far better and safer. Combo-pilling will be the newest fad or in addition to this the newest ahead under scrutiny and therefore it is just more publicly known recently, comb-pilling for weight loss has been around since the eighties. The biggest reason that employing a combination of pills is now popular will be the fact that at the time of right now there are no long term prescription weight loss supplements that have been licensed by the FDA other than orlistat. The truly disturbing part is doctors are prescribing these combinations of medications however some of the combinations are already rejected or have yet to be approved by the FDA. Seizures are a side effect with Contrave and must not be taken in those with seizure disorders. The drug may also raise blood pressure level and heart rate, and shouldn't be used in individuals with a history of cardiac event or stroke in the last six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy using the drug. The FDA also warned that Contrave can raise blood pressure and pulse rate and must not be used in patients with uncontrolled high blood pressure, along with by anyone with heart-related and cerebrovascular (circulation system dysfunction impacting the mind) disease. Patients using a history of heart attack or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes using a boxed warning to alert health care professionals and patients to the increased chance of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for quitting smoking. The residential Vivitrol Treatment in Vivitrol Rehab centre begins with detoxification where patients are shown painkilling medicines to avoid any withdrawal negative effects. Then there is the stage where patience is treated for blood glucose levels, high blood pressure levels, heart diseases that happen to be common aliments associated with an alcoholic. In the Vivitrol Rehab centers, the above stage is followed by psychological support and psychiatric treatment where family members are also being involved to support the patient mentally and emotionally. Counseling is an important part of takes place.